This idea deserves a full essay, but for now, consider: In the same way that Apple took Mac OS X and Cocoa and shrunk them to serve as a handheld device OS, I think Google could take Android and grow it to serve as a PC OS. Wine would be to Android what Classic was to Mac OS X.
The big win is saying “screw you” to KDE and Gnome and all those crap Linux interfaces and APIs. Start over with something new, cohesive, better, and, most of all, which is not, conceptually, a watered down clone of Windows.
I’m really not sure where Gruber is going with this. Google seems to like Wine for various reasons (mainly Picasa), but I don’t really understand how it could vault Android into desktop fame. It seems Wine is a “watered down clone” of Windows (its internals, anyway) and I don’t really see much future in it.
Obviously Gruber and I disagree on the various successes of the “open-source desktop” mission, but I don’t think Wine is the way to success.
John, I await your full essay; perhaps I misunderstand?